The Secure and Energy Efficient Data Routing in the IoT based Network

The business applications such as weather forecasting, traffic management, weather forecasting, traffic management, etc., are enormously adopting Internet of Things(IoT). While scaling of these applications are fast, the device/sensor capabilities, particularly in terms of battery life and energy efficiency is limited. Despite of intensive research conducted to address these shortcomings, Wireless IoT Sensor Network(WIoTSN) still cannot assure 100\% efficient network life. Therefore, the core objective of the thesis is to provide an overview of energy efficiency of proactive(OLSR) and reactive(DSR and AODV) data routing protocols by scaling the size of network, i.e. number of sensor nodes, data packet size, data transmission rate and speed of mobile sink node. It also reviews the importance of security in WIoTSN. The two approaches, such as literature review and simulation testing, are used to achieve the objective of the thesis. The literature review provides information about reactive and proactive protocols and their mechanism for route discovery. Similarly, the network simulator tool NS3 is used for running simulation to evaluate the performance of selected routing protocols for energy efficiency. The thesis results showed the effect of scaling the parameters selected for experimental purpose on the energy efficiency of proactive and reactive data routing protocols. The simulation results prove that the reactive protocol DSR outperforms another reactive protocol AODV and proactive protocol OLSR in energy efficiency. From the security perspective, the thesis also emphasizes its need in IoT and suggest to minimize wasteful resources in WIoTSN and use them by restructuring the network for secure energy-efficient data routing protocols

A Critically Ill Child with Gangrenous Appendicitis Masquerading as Hollow Viscous Perforation

Background. Severe complications of acute appendicitis (AA) hitherto well described are less common in clinical practice nowadays. When a septic child is encountered with a short history of abdominal symptoms and disproportionate signs of peritonitis further complicated by radiological findings causing a diagnostic conundrum, management becomes exceedingly demanding. Case Presentation. A 10-year-old previously healthy boy presented to the emergency room with generalized abdominal pain associated with fever and jaundice for a day. Blood workup revealed leucopenia, hyperbilirubinemia, hyponatremia, and elevated CRP. Initial radiological evaluation suggested hollow viscous perforation. He was diagnosed to have hollow viscous perforation peritonitis in severe sepsis. At laparotomy, generalized peritoneal contamination was found, the source of which could be traced down to the gangrenous perforated appendix. Conclusion. Complicated appendicitis, in children, can present with baffling findings. Timely identification of an ill child, adequate workup, prompt resuscitation, and source control are imperative for a successful outcome

Scar Endometriosis: A Rare Cause of Abdominal Pain

Scar endometriosis or incisional endometriosis is the presence of endometrial tissues with glands in the previous incision or scar. Its overall estimated incidence after post-cesarean and post-hysterectomy is 0.03–0.4% and 1.08–2%, respectively. The patient presents with non-specific symptoms such as cyclical abdominal pain at the site of a previous surgical incision and scar and an abdominal lump with a cyclical increment in size, which is tender. The diagnosis is made only after the surgical excision with confirmation by histopathological analysis. We present the case of a 31-year-old female complaining of cyclical abdominal pain and a lump on the right side of a Pfannenstiel incision for five months. She had undergone two Lower Segment Caesarean Sections (LSCSs); the last surgery was eight months prior. Surgical excision was planned with the corresponding clinical features and radiological data. After the surgical excision, the sample was sent for histopathological examination, and scar endometriosis was diagnosed

Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer

AbstractStructural tailoring of the flavone framework (position 7) via organopalladium-catalyzed C–C bond formation was attempted in this study. The impact of substituents with varied electronic effects (phenyl ring, position 2 of the benzopyran scaffold) on the antitumor properties was also assessed. Resultantly, the efforts yielded a furyl arm bearing benzopyran possessing a 4-fluoro phenyl ring (position 2) (14) that manifested a magnificent antitumor profile against the Ishikawa cell lines mediated through dual inhibition of PARP and tubulin [(IC50 (PARP1) = 74 nM, IC50 (PARP2) = 109 nM) and tubulin (IC50 = 1.4 µM)]. Further investigations confirmed the ability of 14 to induce apoptosis as well as autophagy and cause cell cycle arrest at the G2/M phase. Overall, the outcome of the study culminated in a tractable dual PARP-tubulin inhibitor endowed with an impressive activity profile against endometrial cancer